Anle138b partly ameliorates motor deficits despite failure of neuroprotection in a model of advanced multiple system atrophy

Anle138b partly ameliorates motor deficits despite failure of neuroprotection in a model of advanced multiple system atrophy

The neurodegenerative disorder multiple system atrophy (MSA) is characterized by autonomic failure, cerebellar ataxia and parkinsonism in any combination associated with predominantly oligodendroglial α-synuclein (α-syn) aggregates (glial cytoplasmic inclusions=GCIs). To date, there is no effective...

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Bibliographic Details
Main Authors: Lisa eFellner, Daniela eKuzdas-Wood, Johannes eLevin, Sergey eRyazanov, Andrei eLeonov, Christian eGriesinger, Armin eGiese, Gregor K Wenning, Nadia eStefanova
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Neuroscience
Subjects:
Multiple System Atrophy
α-Synuclein
Glial cytoplasmic inclusions
3- Nitropropionic acid
Anle138b
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00099/full

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http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00099/full

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