Co-Expression of IL-7 Improves NKG2D-Based CAR T Cell Therapy on Prostate Cancer by Enhancing the Expansion and Inhibiting the Apoptosis and Exhaustion

Co-Expression of IL-7 Improves NKG2D-Based CAR T Cell Therapy on Prostate Cancer by Enhancing the Expansion and Inhibiting the Apoptosis and Exhaustion

Chimeric antigen receptor (CAR) T-cell therapy is a promising approach in treating solid tumors but the therapeutic effect is limited. Prostate cancer is a typical solid malignancy with invasive property and a highly immunosuppressive microenvironment. Ligands for the NKG2D receptor are primarily ex...

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Bibliographic Details
Main Authors: Cong He, Ying Zhou, Zhenlong Li, Muhammad Asad Farooq, Iqra Ajmal, Hongmei Zhang, Li Zhang, Lei Tao, Jie Yao, Bing Du, Mingyao Liu, Wenzheng Jiang
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
NKG2D
CAR T
IL-7
prostate cancer
cell therapy
Online Access:https://www.mdpi.com/2072-6694/12/7/1969

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