Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis

Mammalian eggs require a single sperm for viable fertilization, and cortical granule exocytosis prevents additional sperm binding. Vogt et al. image at single granule resolution to document that cortical granule anchoring in the cortex ensures proper trafficking, exocytosis and polyspermy block.

Bibliographic Details
Main Authors:	Edgar-John Vogt, Keizo Tokuhiro, Min Guo, Ryan Dale, Guanghui Yang, Seung-Wook Shin, Maria Jimenez Movilla, Hari Shroff, Jurrien Dean
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10171-7

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spelling	doaj-e6424900b9c54c2f9956c43155b7d5da2021-05-11T12:37:51ZengNature Publishing GroupNature Communications2041-17232019-05-0110111310.1038/s41467-019-10171-7Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosisEdgar-John Vogt0Keizo Tokuhiro1Min Guo2Ryan Dale3Guanghui Yang4Seung-Wook Shin5Maria Jimenez Movilla6Hari Shroff7Jurrien Dean8Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of HealthLaboratory of Cellular and Developmental Biology, NIDDK, National Institutes of HealthSection on High Resolution Optical Imaging, NIBIB, National Institutes of HealthLaboratory of Cellular and Developmental Biology, NIDDK, National Institutes of HealthLaboratory of Cellular and Developmental Biology, NIDDK, National Institutes of HealthLaboratory of Cellular and Developmental Biology, NIDDK, National Institutes of HealthDepartment of Cell Biology and Histology, Medical School, University of Murcia, IMIBSection on High Resolution Optical Imaging, NIBIB, National Institutes of HealthLaboratory of Cellular and Developmental Biology, NIDDK, National Institutes of HealthMammalian eggs require a single sperm for viable fertilization, and cortical granule exocytosis prevents additional sperm binding. Vogt et al. image at single granule resolution to document that cortical granule anchoring in the cortex ensures proper trafficking, exocytosis and polyspermy block.https://doi.org/10.1038/s41467-019-10171-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Edgar-John Vogt Keizo Tokuhiro Min Guo Ryan Dale Guanghui Yang Seung-Wook Shin Maria Jimenez Movilla Hari Shroff Jurrien Dean
spellingShingle	Edgar-John Vogt Keizo Tokuhiro Min Guo Ryan Dale Guanghui Yang Seung-Wook Shin Maria Jimenez Movilla Hari Shroff Jurrien Dean Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis Nature Communications
author_facet	Edgar-John Vogt Keizo Tokuhiro Min Guo Ryan Dale Guanghui Yang Seung-Wook Shin Maria Jimenez Movilla Hari Shroff Jurrien Dean
author_sort	Edgar-John Vogt
title	Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis
title_short	Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis
title_full	Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis
title_fullStr	Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis
title_full_unstemmed	Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis
title_sort	anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-05-01
description	Mammalian eggs require a single sperm for viable fertilization, and cortical granule exocytosis prevents additional sperm binding. Vogt et al. image at single granule resolution to document that cortical granule anchoring in the cortex ensures proper trafficking, exocytosis and polyspermy block.
url	https://doi.org/10.1038/s41467-019-10171-7
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Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis

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