Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis

Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis

Mammalian eggs require a single sperm for viable fertilization, and cortical granule exocytosis prevents additional sperm binding. Vogt et al. image at single granule resolution to document that cortical granule anchoring in the cortex ensures proper trafficking, exocytosis and polyspermy block.

Bibliographic Details
Main Authors: Edgar-John Vogt, Keizo Tokuhiro, Min Guo, Ryan Dale, Guanghui Yang, Seung-Wook Shin, Maria Jimenez Movilla, Hari Shroff, Jurrien Dean
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10171-7
Description
Summary:Mammalian eggs require a single sperm for viable fertilization, and cortical granule exocytosis prevents additional sperm binding. Vogt et al. image at single granule resolution to document that cortical granule anchoring in the cortex ensures proper trafficking, exocytosis and polyspermy block.
ISSN:2041-1723

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