Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines

Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines

Background: COX-2 and E-cadherin, involved in invasion and metastasis, are molecules critical for gastric carcinogenesis. A relationship between them is documented in non-small cell lung and prostate cancer. We present novel evidence of a relationship between COX-2 and E-cadherin expression in gastr...

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Main Authors: R. Sitarz, R. J. Leguit, W. W. J. de Leng, F. H. M. Morsink, W. P. Polkowski, R. Maciejewski, G. J. A. Offerhaus, A. N. Milne
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:Cellular Oncology
Online Access:http://dx.doi.org/10.3233/CLO-2009-0496
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spelling doaj-e63dbf24a9a049baa19cdf9376f7904f2020-11-24T20:40:23ZengHindawi LimitedCellular Oncology1570-58701875-86062009-01-0131647548510.3233/CLO-2009-0496Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell LinesR. Sitarz0R. J. Leguit1W. W. J. de Leng2F. H. M. Morsink3W. P. Polkowski4R. Maciejewski5G. J. A. Offerhaus6A. N. Milne7Department of Pathology, University Medical Centre, Utrecht, The NetherlandsDepartment of Pathology, University Medical Centre, Utrecht, The NetherlandsDepartment of Pathology, University Medical Centre, Utrecht, The NetherlandsDepartment of Pathology, University Medical Centre, Utrecht, The NetherlandsDepartment of Surgical Oncology, Medical University of Lublin, Lublin, PolandDepartment of Human Anatomy, Medical University of Lublin, Lublin, PolandDepartment of Pathology, University Medical Centre, Utrecht, The NetherlandsDepartment of Pathology, University Medical Centre, Utrecht, The NetherlandsBackground: COX-2 and E-cadherin, involved in invasion and metastasis, are molecules critical for gastric carcinogenesis. A relationship between them is documented in non-small cell lung and prostate cancer. We present novel evidence of a relationship between COX-2 and E-cadherin expression in gastric cancer.http://dx.doi.org/10.3233/CLO-2009-0496
collection DOAJ
language English
format Article
sources DOAJ
author R. Sitarz
R. J. Leguit
W. W. J. de Leng
F. H. M. Morsink
W. P. Polkowski
R. Maciejewski
G. J. A. Offerhaus
A. N. Milne
spellingShingle R. Sitarz
R. J. Leguit
W. W. J. de Leng
F. H. M. Morsink
W. P. Polkowski
R. Maciejewski
G. J. A. Offerhaus
A. N. Milne
Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines
Cellular Oncology
author_facet R. Sitarz
R. J. Leguit
W. W. J. de Leng
F. H. M. Morsink
W. P. Polkowski
R. Maciejewski
G. J. A. Offerhaus
A. N. Milne
author_sort R. Sitarz
title Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines
title_short Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines
title_full Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines
title_fullStr Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines
title_full_unstemmed Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines
title_sort cyclooxygenase-2 mediated regulation of e-cadherin occurs in conventional but not early-onset gastric cancer cell lines
publisher Hindawi Limited
series Cellular Oncology
issn 1570-5870
1875-8606
publishDate 2009-01-01
description Background: COX-2 and E-cadherin, involved in invasion and metastasis, are molecules critical for gastric carcinogenesis. A relationship between them is documented in non-small cell lung and prostate cancer. We present novel evidence of a relationship between COX-2 and E-cadherin expression in gastric cancer.
url http://dx.doi.org/10.3233/CLO-2009-0496
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AT rjleguit cyclooxygenase2mediatedregulationofecadherinoccursinconventionalbutnotearlyonsetgastriccancercelllines
AT wwjdeleng cyclooxygenase2mediatedregulationofecadherinoccursinconventionalbutnotearlyonsetgastriccancercelllines
AT fhmmorsink cyclooxygenase2mediatedregulationofecadherinoccursinconventionalbutnotearlyonsetgastriccancercelllines
AT wppolkowski cyclooxygenase2mediatedregulationofecadherinoccursinconventionalbutnotearlyonsetgastriccancercelllines
AT rmaciejewski cyclooxygenase2mediatedregulationofecadherinoccursinconventionalbutnotearlyonsetgastriccancercelllines
AT gjaofferhaus cyclooxygenase2mediatedregulationofecadherinoccursinconventionalbutnotearlyonsetgastriccancercelllines
AT anmilne cyclooxygenase2mediatedregulationofecadherinoccursinconventionalbutnotearlyonsetgastriccancercelllines
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