Relationship between serum indicators, endothelial injury markers and renal damage in patients with ANCA-associated systemic vasculitis

• Main Authors: Wei-Jia Liu, Jun-Bo Huang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-05-01
• Series: Journal of Hainan Medical University
• Subjects: ANCA-associated systemic vasculitis; Autoantibody; Endothelial injury; Renal damage
• Online Access: http://www.hnykdxxb.com/PDF/201610/12.pdf

Objective: To study the relationship between serum indicators, endothelial injury markers and renal damage in patients with ANCA-associated systemic vasculitis. Methods: Patients with ANCA-associated systemic vasculitis were selected for study, 30 cases of patients not complicated with renal damage were screened as AAV group and 30 cases of patients complicated with renal damage were screened as renal damage group, and then serum autoantibody contents and endothelial injury marker contents were detected. Results: Serum PR3-ANCA and MPO-ANCA contents of renal damage group were not statistically different from those of AAV group while anti-LAMP-2 antibody and AECA contents were significantly higher than those of AAV group; serum CECs, vWF, ES and VCAM-1 contents of renal damage group were significantly higher than those of AAV group while TM and eNOS contents were lower than those of AAV group; the higher the CKD stage in renal damage group, the more significant the albuminuria, the higher the serum CECs, vWF, ES and VCAM-1 contents and the lower the TM and eNOS contents. Conclusion: Abnormal contents of serum autoantibody anti-LAMP-2 antibody, AECA and endothelial injury markers in patients with ANCA-associated systemic vasculitis are closely related to renal damage and can be used for disease evaluation.