Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2

Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2

Summary: Actinins are strain-sensing actin cross-linkers that are ubiquitously expressed and harbor mutations in human diseases. We utilize CRISPR, pluripotent stem cells, and BioID to study actinin interactomes in human cardiomyocytes. We identify 324 actinin proximity partners, including those tha...

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Bibliographic Details
Main Authors: Feria A. Ladha, Ketan Thakar, Anthony M. Pettinato, Nicholas Legere, Shahnaz Ghahremani, Rachel Cohn, Robert Romano, Emily Meredith, Yu-Sheng Chen, J. Travis Hinson
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
sarcomere
actinin
BioID
quantitative proteomics
RNA-binding proteins
oxidative phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721009426

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http://www.sciencedirect.com/science/article/pii/S2211124721009426

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