Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

The wiring of peripheral neural circuits that regulate heart rate is poorly understood. In this study, authors used tissue clearing for high-resolution characterization of nerves in the heart in 3D and transgenic and novel viral vector approaches to identify peripheral parasympathetic and sympatheti...

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Main Authors:	Pradeep S. Rajendran, Rosemary C. Challis, Charless C. Fowlkes, Peter Hanna, John D. Tompkins, Maria C. Jordan, Sarah Hiyari, Beth A. Gabris-Weber, Alon Greenbaum, Ken Y. Chan, Benjamin E. Deverman, Heike Münzberg, Jeffrey L. Ardell, Guy Salama, Viviana Gradinaru, Kalyanam Shivkumar
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09770-1

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spelling	doaj-e62e7c209ae04211ac168bacbbdd12fb2021-05-11T12:03:43ZengNature Publishing GroupNature Communications2041-17232019-04-0110111310.1038/s41467-019-09770-1Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategiesPradeep S. Rajendran0Rosemary C. Challis1Charless C. Fowlkes2Peter Hanna3John D. Tompkins4Maria C. Jordan5Sarah Hiyari6Beth A. Gabris-Weber7Alon Greenbaum8Ken Y. Chan9Benjamin E. Deverman10Heike Münzberg11Jeffrey L. Ardell12Guy Salama13Viviana Gradinaru14Kalyanam Shivkumar15Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)Division of Biology and Biological Engineering, California Institute of TechnologyDepartment of Computer Science, University of California - IrvineCardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)Department of Cell Biology, University of PittsburghDivision of Biology and Biological Engineering, California Institute of TechnologyDivision of Biology and Biological Engineering, California Institute of TechnologyDivision of Biology and Biological Engineering, California Institute of TechnologyNeurobiology of Nutrition and Metabolism Department, Louisiana State UniversityCardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)Department of Cell Biology, University of PittsburghDivision of Biology and Biological Engineering, California Institute of TechnologyCardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA)The wiring of peripheral neural circuits that regulate heart rate is poorly understood. In this study, authors used tissue clearing for high-resolution characterization of nerves in the heart in 3D and transgenic and novel viral vector approaches to identify peripheral parasympathetic and sympathetic neuronal populations involved in heart rate control in mice.https://doi.org/10.1038/s41467-019-09770-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pradeep S. Rajendran Rosemary C. Challis Charless C. Fowlkes Peter Hanna John D. Tompkins Maria C. Jordan Sarah Hiyari Beth A. Gabris-Weber Alon Greenbaum Ken Y. Chan Benjamin E. Deverman Heike Münzberg Jeffrey L. Ardell Guy Salama Viviana Gradinaru Kalyanam Shivkumar
spellingShingle	Pradeep S. Rajendran Rosemary C. Challis Charless C. Fowlkes Peter Hanna John D. Tompkins Maria C. Jordan Sarah Hiyari Beth A. Gabris-Weber Alon Greenbaum Ken Y. Chan Benjamin E. Deverman Heike Münzberg Jeffrey L. Ardell Guy Salama Viviana Gradinaru Kalyanam Shivkumar Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies Nature Communications
author_facet	Pradeep S. Rajendran Rosemary C. Challis Charless C. Fowlkes Peter Hanna John D. Tompkins Maria C. Jordan Sarah Hiyari Beth A. Gabris-Weber Alon Greenbaum Ken Y. Chan Benjamin E. Deverman Heike Münzberg Jeffrey L. Ardell Guy Salama Viviana Gradinaru Kalyanam Shivkumar
author_sort	Pradeep S. Rajendran
title	Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
title_short	Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
title_full	Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
title_fullStr	Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
title_full_unstemmed	Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
title_sort	identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-04-01
description	The wiring of peripheral neural circuits that regulate heart rate is poorly understood. In this study, authors used tissue clearing for high-resolution characterization of nerves in the heart in 3D and transgenic and novel viral vector approaches to identify peripheral parasympathetic and sympathetic neuronal populations involved in heart rate control in mice.
url	https://doi.org/10.1038/s41467-019-09770-1
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Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

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