The natural function of the malaria parasite’s chloroquine resistance transporter

Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or metabolites, and that drug-resistance-conferring PfCRT...

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Main Authors:	Sarah H. Shafik, Simon A. Cobbold, Kawthar Barkat, Sashika N. Richards, Nicole S. Lancaster, Manuel Llinás, Simon J. Hogg, Robert L. Summers, Malcolm J. McConville, Rowena E. Martin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17781-6

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spelling	doaj-e62a9cfeb1b74e3793184dbfb72b16f72021-08-08T11:38:27ZengNature Publishing GroupNature Communications2041-17232020-08-0111111610.1038/s41467-020-17781-6The natural function of the malaria parasite’s chloroquine resistance transporterSarah H. Shafik0Simon A. Cobbold1Kawthar Barkat2Sashika N. Richards3Nicole S. Lancaster4Manuel Llinás5Simon J. Hogg6Robert L. Summers7Malcolm J. McConville8Rowena E. Martin9Research School of Biology, The Australian National UniversityBio21 Molecular Science and Biotechnology Institute, University of MelbourneResearch School of Biology, The Australian National UniversityResearch School of Biology, The Australian National UniversityResearch School of Biology, The Australian National UniversityDepartment of Biochemistry and Molecular Biology, Department of Chemistry, and Huck Center for Malaria Research, The Pennsylvania State UniversityResearch School of Biology, The Australian National UniversityResearch School of Biology, The Australian National UniversityBio21 Molecular Science and Biotechnology Institute, University of MelbourneResearch School of Biology, The Australian National UniversityPlasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or metabolites, and that drug-resistance-conferring PfCRT mutants have reduced peptide transport.https://doi.org/10.1038/s41467-020-17781-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sarah H. Shafik Simon A. Cobbold Kawthar Barkat Sashika N. Richards Nicole S. Lancaster Manuel Llinás Simon J. Hogg Robert L. Summers Malcolm J. McConville Rowena E. Martin
spellingShingle	Sarah H. Shafik Simon A. Cobbold Kawthar Barkat Sashika N. Richards Nicole S. Lancaster Manuel Llinás Simon J. Hogg Robert L. Summers Malcolm J. McConville Rowena E. Martin The natural function of the malaria parasite’s chloroquine resistance transporter Nature Communications
author_facet	Sarah H. Shafik Simon A. Cobbold Kawthar Barkat Sashika N. Richards Nicole S. Lancaster Manuel Llinás Simon J. Hogg Robert L. Summers Malcolm J. McConville Rowena E. Martin
author_sort	Sarah H. Shafik
title	The natural function of the malaria parasite’s chloroquine resistance transporter
title_short	The natural function of the malaria parasite’s chloroquine resistance transporter
title_full	The natural function of the malaria parasite’s chloroquine resistance transporter
title_fullStr	The natural function of the malaria parasite’s chloroquine resistance transporter
title_full_unstemmed	The natural function of the malaria parasite’s chloroquine resistance transporter
title_sort	natural function of the malaria parasite’s chloroquine resistance transporter
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-08-01
description	Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or metabolites, and that drug-resistance-conferring PfCRT mutants have reduced peptide transport.
url	https://doi.org/10.1038/s41467-020-17781-6
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The natural function of the malaria parasite’s chloroquine resistance transporter

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