Pathophysiological significance of the two-pore domain K+ channel K2P5.1 in splenic CD4+CD25- T cell subset from a chemically-induced murine inflammatory bowel disease model

Pathophysiological significance of the two-pore domain K+ channel K2P5.1 in splenic CD4+CD25- T cell subset from a chemically-induced murine inflammatory bowel disease model

The alkaline pH-activated, two-pore domain K+ channel K2P5.1 (also known as TASK2/KCNK5) plays an important role in maintaining the resting membrane potential, and contributes to the control of Ca2+ signaling in several types of cells. Recent studies highlighted the potential role of the K2P5.1 K+ c...

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Bibliographic Details
Main Authors: Sawa eNakakura, Miki eMatsui, Aya eSato, Mizuki eIshii, Kyoko eEndo, Sayaka eMuragishi, Miki eMurase, Hiroaki eKito, Hiroki eNiguma, Natsumi eKurokawa, Masanori eFujii, Masatake eAraki, Kimi eAraki, Susumu eOhya
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Physiology
Subjects:
inflammatory bowel disease
Ca2+ influx
CD4+ T cell
Cytokine expression
background K+ channel
K2P5.1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00299/full

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