Correlation of serum uric acid level with neurotrophy, nerve injury and systemic oxidative stress response in patients with Parkinson's disease
Objective: To investigate the correlation of serum uric acid level with neurotrophy, nerve injury and systemic oxidative stress response in patients with Parkinson's disease. Methods: A total of 60 patients with Parkinson’s disease who were diagnosed and treated in our hospital between July...
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2018-10-01
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| Series: | Journal of Hainan Medical University |
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| Online Access: | http://www.hnykdxxb.com/PDF/201820/07.pdf |
| Summary: | Objective: To investigate the correlation of serum uric acid level with neurotrophy, nerve
injury and systemic oxidative stress response in patients with Parkinson's disease. Methods:
A total of 60 patients with Parkinson’s disease who were diagnosed and treated in our hospital
between July 2014 and February 2018 were enrolled in Parkinson's disease group, and 100
healthy elderly people who received physical examination in our hospital during the same
period were enrolled in normal control group. The differences in serum uric acid levels as
well as the contents of indexes related to neurotrophy, nerve injury and oxidative stress were
compared between the two groups, and Pearson test was used to evaluate the correlation of
serum uric acid level with indexes related to neurotrophy, nerve injury and oxidative stress in
patients with Parkinson's disease. Results: Serum uric acid level of PD group was lower than
that of normal control group; serum neurotrophy indexes BDNF, GDNF and NGF contents
were lower than those of normal control group; serum nerve injury indexes YKL-40 and S-100B
contents were higher than those of normal control group whereas IGF-1 content was lower
than that of normal control group; serum oxidative stress indexes GPX and CAT contents were
lower than those of normal control group whereas MDA and LHP contents were higher than
those of normal control group. Correlation analysis confirmed that the serum uric acid level of
patients with Parkinson's disease was directly correlated to the indexes related to neurotrophy,
nerve injury and oxidative stress. Conclusion: The abnormal decrease of serum uric acid level
in patients with Parkinson's disease is directly correlated with the neurotrophy, nerve injury,
oxidative stress response, and so on. |
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| ISSN: | 1007-1237 1007-1237 |