Leflunomide Induces Dose-Dependent Lung Injury in Mice via Stimulating Vimentin and NLRP3 Inflammasome Production

Leflunomide Induces Dose-Dependent Lung Injury in Mice via Stimulating Vimentin and NLRP3 Inflammasome Production

Recently, the therapeutic importance of the anti-rheumatic drug, leflunomide, has been increased after the involvement of leflunomide in treating other autoimmune diseases and its promising role in retarding human malignancies. Few studies have focused on the safety in human or animals without clear...

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Bibliographic Details
Main Authors: Mohamed El-Sherbiny, Hoda Atef, Mohamed Ahmed Eladl, Abdelaty Shawky Mohamed, Mohamed El-Shafey, Howaida S. Ali, Sawsan A. Zaitone, Suliman Y. Alomar, Saeed Awad M. Alqahtani, Sheka Yagub Aloyouni, Mohammed A. Attia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
collagen 1
fibrosis
leflunomide
lung injury
mouse
NLRP3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.631216/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.631216/full

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