The Number of Transcription Factors at an Enhancer Determines Switch-like Gene Expression

The Number of Transcription Factors at an Enhancer Determines Switch-like Gene Expression

Summary: NF-κB is a transcription factor that activates super enhancers (SEs) and typical enhancers (TEs) and triggers threshold and graded gene expression, respectively. However, the mechanisms by which NF-κB selectively participates in these enhancers remain unclear. Here we show using mouse prima...

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Bibliographic Details
Main Authors: Hiroki Michida, Hiroaki Imoto, Hisaaki Shinohara, Noriko Yumoto, Masahide Seki, Mana Umeda, Tetsutaro Hayashi, Itoshi Nikaido, Takeya Kasukawa, Yutaka Suzuki, Mariko Okada-Hatakeyama
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
enhancer
transcriptional regulation
transcription factor
NF-κB
B cell
mathematical model
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720307014

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