PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice

PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice

piRNAs are regulatory RNAs that play a critical role in transposon silencing and gametogenesis. Here, the authors provide evidence that mammalian PNLDC1 is a regulator of piRNA biogenesis, transposon silencing and spermatogenesis, protecting the germline genome in mice.

Bibliographic Details
Main Authors: Deqiang Ding, Jiali Liu, Kunzhe Dong, Uros Midic, Rex A. Hess, Huirong Xie, Elena Y. Demireva, Chen Chen
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00854-4
Description
Summary:piRNAs are regulatory RNAs that play a critical role in transposon silencing and gametogenesis. Here, the authors provide evidence that mammalian PNLDC1 is a regulator of piRNA biogenesis, transposon silencing and spermatogenesis, protecting the germline genome in mice.
ISSN:2041-1723

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