AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN
<p align="center"><strong><em>ABSTRACT</em></strong><strong><em></em></strong></p><p align="center"><strong><em> </em></strong></p><p><em>This study is an effort to discove...
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Universitas Jenderal Achmad Yani
2015-06-01
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Series: | Kartika: Jurnal Ilmiah Farmasi |
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doaj-e6145aff94f44d599ad69607869110312020-11-25T03:03:39ZindUniversitas Jenderal Achmad YaniKartika: Jurnal Ilmiah Farmasi2354-65652502-34382015-06-0131202810.26874/kjif.v3i1.9380AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULINYance Anas0Risha Fillah Fithria1Maulita Cut Nuria2Amprih Martha3Agung Endro Nugroho4Puji Astuti5Bagian Farmakologi dan Farmasi Klinik Fakultas Farmasi Universitas Wahid Hasyim SemarangBagian Farmakologi dan Farmasi Klinik Fakultas Farmasi Universitas Wahid Hasyim SemarangBagian Biologi Farmasi Fakultas Farmasi Universitas Wahid Hasyim SemarangBagian Farmakologi dan Farmasi Klinik Fakultas Farmasi Universitas Wahid Hasyim SemarangBagian Farmakologi dan Farmasi Klinik Fakultas Farmasi Universitas Gadjah Mada YogyakartaBagian Biologi Farmasi Fakultas Farmasi Universitas Gadjah Mada Yogyakarta<p align="center"><strong><em>ABSTRACT</em></strong><strong><em></em></strong></p><p align="center"><strong><em> </em></strong></p><p><em>This study is an effort to discover new anti-diabetic compounds from natural products in the type-2 diabetes mellitus treatment. </em><em>The purpose of this study was to determine the potential of n-hexane fraction (FHDL) from lenglengan leaf ethanol extract as an antidiabetic in insulin resistance type-2 diabetic </em><em>Rat</em><em>.</em><em> </em><em>Insulin resistance was induced by administration of long-acting insulin (Lantus<sup>®</sup>) 1.80 IU</em><em>.Kg BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em> for 14 days. </em><em>Insulin resistance rats tested by using parameter fasting blood glucose (FBG), before and after treatment of long-acting insulin</em><em>. </em><em>Rat has to type-2 diabetes due to insulin resistance when </em><em>FBG </em><em>on day 1</em><em>8</em><em> exceeded </em><em>85 </em><em>mg</em><em>.</em><em>dL</em><em><sup>-1</sup></em><em>. </em><em>Test results show the animal had insulin resistant. </em><em> </em><em>Rat with the insulin resistance is divided into five treatment groups consisting of one group of diabetic control </em><em>(treats with CMC-Na 0.5%, 25 mL</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em>), three dose groups of F</em><em>H</em><em>DL (62.5</em><em>; 125 and</em><em> 250) mg</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em> and a positive control group (treats with metformin 150 mg</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em>)</em><em>.</em><em> FHDL and metformin 150 mg.Kg BW<sup>-1</sup>.day<sup>-1</sup> were </em><em>administered once daily for 14 days.</em><em> </em><em>FBG data, before and after treatments were compared. </em><em>FBG assay is using a reagent kit. </em><em>The results showed that FHDL (</em><em>125 and</em><em> 250) mg</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em> </em><em>and metformin 150 mg.Kg BW<sup>-1</sup>.day<sup>-1</sup> are</em><em> shown to have antidiabetic effects in insulin resistance type-2 diabetic rat.</em><em> </em><em>FHDL 250 mg.Kg<sup>-1</sup>.day<sup>-1</sup> antidiabetic effect (25.87%) is equivalent to metformin 150 mg.Kg BW<sup>-1</sup>.day<sup>-1</sup> (21.50) (p>0.05). </em><em>T</em><em>he results of this research can proceed to find the novel antidiabetic compound from the lenglengan leaf ethanol extracts.</em><em></em></p><p><strong><em> </em></strong></p><p><strong><em>Key words : </em></strong><em>n-Hexane fraction, Lenglengan extract, </em><em>Anti-diabetic</em><em> effects</em><em>,</em><em> I</em><em>nsulin resistance, </em><em>T</em><em>ype-2 diabetic rats.</em><em></em></p><p><strong><em> </em></strong></p>http://kjif.unjani.ac.id/index.php/kjif/article/view/93 |
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DOAJ |
language |
Indonesian |
format |
Article |
sources |
DOAJ |
author |
Yance Anas Risha Fillah Fithria Maulita Cut Nuria Amprih Martha Agung Endro Nugroho Puji Astuti |
spellingShingle |
Yance Anas Risha Fillah Fithria Maulita Cut Nuria Amprih Martha Agung Endro Nugroho Puji Astuti AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN Kartika: Jurnal Ilmiah Farmasi |
author_facet |
Yance Anas Risha Fillah Fithria Maulita Cut Nuria Amprih Martha Agung Endro Nugroho Puji Astuti |
author_sort |
Yance Anas |
title |
AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN |
title_short |
AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN |
title_full |
AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN |
title_fullStr |
AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN |
title_full_unstemmed |
AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN |
title_sort |
aktivitas antidiabetes fraksi n-heksan ekstrak etanol daun lenglengan (leucas lavandulifolia je. smith) pada tikus dm tipe-2 yang mengalami resistensi insulin |
publisher |
Universitas Jenderal Achmad Yani |
series |
Kartika: Jurnal Ilmiah Farmasi |
issn |
2354-6565 2502-3438 |
publishDate |
2015-06-01 |
description |
<p align="center"><strong><em>ABSTRACT</em></strong><strong><em></em></strong></p><p align="center"><strong><em> </em></strong></p><p><em>This study is an effort to discover new anti-diabetic compounds from natural products in the type-2 diabetes mellitus treatment. </em><em>The purpose of this study was to determine the potential of n-hexane fraction (FHDL) from lenglengan leaf ethanol extract as an antidiabetic in insulin resistance type-2 diabetic </em><em>Rat</em><em>.</em><em> </em><em>Insulin resistance was induced by administration of long-acting insulin (Lantus<sup>®</sup>) 1.80 IU</em><em>.Kg BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em> for 14 days. </em><em>Insulin resistance rats tested by using parameter fasting blood glucose (FBG), before and after treatment of long-acting insulin</em><em>. </em><em>Rat has to type-2 diabetes due to insulin resistance when </em><em>FBG </em><em>on day 1</em><em>8</em><em> exceeded </em><em>85 </em><em>mg</em><em>.</em><em>dL</em><em><sup>-1</sup></em><em>. </em><em>Test results show the animal had insulin resistant. </em><em> </em><em>Rat with the insulin resistance is divided into five treatment groups consisting of one group of diabetic control </em><em>(treats with CMC-Na 0.5%, 25 mL</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em>), three dose groups of F</em><em>H</em><em>DL (62.5</em><em>; 125 and</em><em> 250) mg</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em> and a positive control group (treats with metformin 150 mg</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em>)</em><em>.</em><em> FHDL and metformin 150 mg.Kg BW<sup>-1</sup>.day<sup>-1</sup> were </em><em>administered once daily for 14 days.</em><em> </em><em>FBG data, before and after treatments were compared. </em><em>FBG assay is using a reagent kit. </em><em>The results showed that FHDL (</em><em>125 and</em><em> 250) mg</em><em>.K</em><em>g</em><em> BW<sup>-1</sup>.</em><em>day</em><em><sup>-1</sup></em><em> </em><em>and metformin 150 mg.Kg BW<sup>-1</sup>.day<sup>-1</sup> are</em><em> shown to have antidiabetic effects in insulin resistance type-2 diabetic rat.</em><em> </em><em>FHDL 250 mg.Kg<sup>-1</sup>.day<sup>-1</sup> antidiabetic effect (25.87%) is equivalent to metformin 150 mg.Kg BW<sup>-1</sup>.day<sup>-1</sup> (21.50) (p>0.05). </em><em>T</em><em>he results of this research can proceed to find the novel antidiabetic compound from the lenglengan leaf ethanol extracts.</em><em></em></p><p><strong><em> </em></strong></p><p><strong><em>Key words : </em></strong><em>n-Hexane fraction, Lenglengan extract, </em><em>Anti-diabetic</em><em> effects</em><em>,</em><em> I</em><em>nsulin resistance, </em><em>T</em><em>ype-2 diabetic rats.</em><em></em></p><p><strong><em> </em></strong></p> |
url |
http://kjif.unjani.ac.id/index.php/kjif/article/view/93 |
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