PROGNOSTIC FACTORS OF PROSTATE CANCER BEFORE AND AFTER RADICAL PROSTATECTOMY

• Main Authors: E. I. Veliev, V. E. Okhrits, A. Kh. Obeid
• Format: Article
• Language: Russian
• Published: ABV-press 2014-07-01
• Series: Onkourologiâ
• Subjects: prostate cancer; radical prostatectomy; positive surgical margin; prognostic factor
• Online Access: http://oncourology.abvpress.ru/index.php/oncur/article/view/155

<p><strong>Objective: </strong>to assess a correlation between the preoperative prognostic characteristics and the pathologic stage and to determine whether a positive surgical margin is present after radical prostatectomy (RPE).</p><p><strong>Materials and methods. </strong>The materials of 224 patients with prostate cancer (PC) who had undergone RPE at the Clinic of Urology and Surgical Andrology, Russian Medical Academy of Postgraduate Education, were analyzed.</p><p><strong>Results. </strong>The patients’ median age was 62 (43–78) years. Sixty-seven (29.9 %), 46 (20.5%), and 111 (49.6 %) patients were referred to as low-, moderate-, and high-risk groups, respectively. A positive surgical margin was observed in 11.9, 28.3, and 38.7 % of the patients in the low-, moderate-, and high-risk groups, respectively (р = 0.0003). The predictors of a positive surgical margin were the percent of involved biopsy specimens (R = 0.34) and Gleason score (R = 0.31) and perineural invasion. According to multivariate analysis, neither the preoperative level of prostate-specific antigen, nor the clinical stage showed any correlation with the positive surgical margin and the pathologic stage after RPE.</p>