Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of Ferulic Acid Derivatives

Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of Ferulic Acid Derivatives

In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f had p...

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Bibliographic Details
Main Authors: Peng-Xuan Zhang, Hang Lin, Cheng Qu, Yu-Ping Tang, Nian-Guang Li, Jun Kai, Guanxiong Shang, Baoquan Li, Li Zhang, Hui Yan, Pei Liu, Jin-Ao Duan
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2015/376527
Description
Summary:In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f had potent antiplatelet aggregation activity with its IC50 27.6 μmol/L, and 7f can be regarded as a novel potent antiplatelet aggregation candidate.
ISSN:2090-9063
2090-9071

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