Treatment With Endothelin-A Receptor Antagonist BQ123 Attenuates Acute Inflammation in Mice Through T-Cell-Dependent Polymorphonuclear Myeloid-Derived Suppressor Cell Activation

Treatment With Endothelin-A Receptor Antagonist BQ123 Attenuates Acute Inflammation in Mice Through T-Cell-Dependent Polymorphonuclear Myeloid-Derived Suppressor Cell Activation

The endothelin-A receptor antagonist BQ123 is an effective treatment agent for hypertension and obese cardiomyopathy. However, the role of BQ123 in controlling acute inflammatory diseases and its underlying mechanisms are not well understood. Here, we showed that BQ123 activated polymorphonuclear my...

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Bibliographic Details
Main Authors: Ziyang Chen, Xiaogang Zhang, Shuaijun Lv, Zhe Xing, Mengyu Shi, Xinyao Li, Meiqi Chen, Shaowen Zuo, Yingxu Tao, Gang Xiao, Jingping Liu, Yumei He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
endothelin-A receptor antagonist
BQ123
acute inflammation
T-cell dependent manner
polymorphonuclear myeloid-derived suppressor cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.641874/full

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