Fabrication and Characterization of Ceftizoxime-Loaded Pectin Nanocarriers

Ceftizoxime (C13H12N5NaO5S2)is a parenteral, third-generationcephalosporin antibiotic used to treat bacterial infections including ear, nose, and throat infections. In this work, pectin...

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Main Authors:	Pawan Kumar, Vinod Kumar, Ravinder Kumar, Catalin Iulian Pruncu
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Series:	Nanomaterials
Subjects:	Ceftizoxime pectin solvent displacement nanocarriers antibacterial activity
Online Access:	https://www.mdpi.com/2079-4991/10/8/1452

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spelling	doaj-e5fc631a0b81420e8d856fc2b7dcccb82020-11-25T03:25:53ZengMDPI AGNanomaterials2079-49912020-07-01101452145210.3390/nano10081452Fabrication and Characterization of Ceftizoxime-Loaded Pectin NanocarriersPawan Kumar0Vinod Kumar1Ravinder Kumar2Catalin Iulian Pruncu3Department of Materials Science and Nanotechnology, Deenbandhu Chhotu Ram University of Science and Technology, Murthal 131039, IndiaDepartment of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar 125001, IndiaDepartment of Mechanical Engineering, Lovely Professional University, Phagwara 144411, IndiaMechanical Engineering Department, University of Birmingham, Birmingham B15 2TT, UKCeftizoxime (C<sub>13</sub>H<sub>12</sub>N<sub>5</sub>NaO<sub>5</sub>S<sub>2</sub>)is a parenteral, third-generationcephalosporin antibiotic used to treat bacterial infections including ear, nose, and throat infections. In this work, pectin has been used as a nanocarrier for ceftizoxime due to its high biocompatibility and non-toxicity with tunable surface properties. Ceftizoxime-loaded pectin nanocarriers (CPN) were successfully synthesized by the solvent displacement method. Optimization of nanoformulation was done by response surface methodology using Design-Expert software. The optimized formulation examined various in-vitro characterizations such as particle size, morphology, and FTIR studies. TEM results revealed irregular shape nanoparticles within the range of 29–110 nm. The in-vitro drug release using the dialysis method was performed after 24h where nanoformulation showed sustained drug release. Drug-loaded nanoparticles revealed good antimicrobial activity against <i>Bacillus cereus, Bacilluspolymyxa, Enterobacteraerogenes</i>, and<i>Pseudomonasaeruginosa</i>.https://www.mdpi.com/2079-4991/10/8/1452Ceftizoximepectinsolvent displacementnanocarriersantibacterial activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pawan Kumar Vinod Kumar Ravinder Kumar Catalin Iulian Pruncu
spellingShingle	Pawan Kumar Vinod Kumar Ravinder Kumar Catalin Iulian Pruncu Fabrication and Characterization of Ceftizoxime-Loaded Pectin Nanocarriers Nanomaterials Ceftizoxime pectin solvent displacement nanocarriers antibacterial activity
author_facet	Pawan Kumar Vinod Kumar Ravinder Kumar Catalin Iulian Pruncu
author_sort	Pawan Kumar
title	Fabrication and Characterization of Ceftizoxime-Loaded Pectin Nanocarriers
title_short	Fabrication and Characterization of Ceftizoxime-Loaded Pectin Nanocarriers
title_full	Fabrication and Characterization of Ceftizoxime-Loaded Pectin Nanocarriers
title_fullStr	Fabrication and Characterization of Ceftizoxime-Loaded Pectin Nanocarriers
title_full_unstemmed	Fabrication and Characterization of Ceftizoxime-Loaded Pectin Nanocarriers
title_sort	fabrication and characterization of ceftizoxime-loaded pectin nanocarriers
publisher	MDPI AG
series	Nanomaterials
issn	2079-4991
publishDate	2020-07-01
description	Ceftizoxime (C<sub>13</sub>H<sub>12</sub>N<sub>5</sub>NaO<sub>5</sub>S<sub>2</sub>)is a parenteral, third-generationcephalosporin antibiotic used to treat bacterial infections including ear, nose, and throat infections. In this work, pectin has been used as a nanocarrier for ceftizoxime due to its high biocompatibility and non-toxicity with tunable surface properties. Ceftizoxime-loaded pectin nanocarriers (CPN) were successfully synthesized by the solvent displacement method. Optimization of nanoformulation was done by response surface methodology using Design-Expert software. The optimized formulation examined various in-vitro characterizations such as particle size, morphology, and FTIR studies. TEM results revealed irregular shape nanoparticles within the range of 29–110 nm. The in-vitro drug release using the dialysis method was performed after 24h where nanoformulation showed sustained drug release. Drug-loaded nanoparticles revealed good antimicrobial activity against <i>Bacillus cereus, Bacilluspolymyxa, Enterobacteraerogenes</i>, and<i>Pseudomonasaeruginosa</i>.
topic	Ceftizoxime pectin solvent displacement nanocarriers antibacterial activity
url	https://www.mdpi.com/2079-4991/10/8/1452
work_keys_str_mv	AT pawankumar fabricationandcharacterizationofceftizoximeloadedpectinnanocarriers AT vinodkumar fabricationandcharacterizationofceftizoximeloadedpectinnanocarriers AT ravinderkumar fabricationandcharacterizationofceftizoximeloadedpectinnanocarriers AT cataliniulianpruncu fabricationandcharacterizationofceftizoximeloadedpectinnanocarriers
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Fabrication and Characterization of Ceftizoxime-Loaded Pectin Nanocarriers

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