The interhemispheric CA1 circuit governs rapid generalisation but not fear memory
Previous work has documented a slow form of memory generalization although a rapid one is demanded. Here the authors elucidate the role of the interhemispheric CA1-CA1 projection in a form of rapid generalization of contextual fear memory via gradual potentiation of these synapses over 24 h.
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Nature Publishing Group
2017-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02315-4 |
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doaj-e5ed1ddb41cb43e79446c71a5ce434d32021-05-11T07:19:12ZengNature Publishing GroupNature Communications2041-17232017-12-018111010.1038/s41467-017-02315-4The interhemispheric CA1 circuit governs rapid generalisation but not fear memoryHeng Zhou0Gui-Jing Xiong1Liang Jing2Ning-Ning Song3De-Lin Pu4Xun Tang5Xiao-Bing He6Fu-Qiang Xu7Jing-Fei Huang8Ling-Jiang Li9Gal Richter-Levin10Rong-Rong Mao11Qi-Xin Zhou12Yu-Qiang Ding13Lin Xu14Key Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of SciencesKey Laboratory of Arrhythmias, Ministry of Education, East Hospital, and Department of Anatomy and Neurobiology, Collaborative Innovation Center for Brain Science, Tongji University School of MedicineKey Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of SciencesSchool of Life Sciences, University of Science and Technology of ChinaWuhan Institute of Physics and Mathematics, The Chinese Academy of SciencesWuhan Institute of Physics and Mathematics, The Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of SciencesMental Health Institute, Second Xiangya Hospital of Central South UniversityDepartment of Neurobiology and Ethology, and Department of Psychology, University of HaifaKey Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of SciencesKey Laboratory of Arrhythmias, Ministry of Education, East Hospital, and Department of Anatomy and Neurobiology, Collaborative Innovation Center for Brain Science, Tongji University School of MedicineKey Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of SciencesPrevious work has documented a slow form of memory generalization although a rapid one is demanded. Here the authors elucidate the role of the interhemispheric CA1-CA1 projection in a form of rapid generalization of contextual fear memory via gradual potentiation of these synapses over 24 h.https://doi.org/10.1038/s41467-017-02315-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Heng Zhou Gui-Jing Xiong Liang Jing Ning-Ning Song De-Lin Pu Xun Tang Xiao-Bing He Fu-Qiang Xu Jing-Fei Huang Ling-Jiang Li Gal Richter-Levin Rong-Rong Mao Qi-Xin Zhou Yu-Qiang Ding Lin Xu |
| spellingShingle |
Heng Zhou Gui-Jing Xiong Liang Jing Ning-Ning Song De-Lin Pu Xun Tang Xiao-Bing He Fu-Qiang Xu Jing-Fei Huang Ling-Jiang Li Gal Richter-Levin Rong-Rong Mao Qi-Xin Zhou Yu-Qiang Ding Lin Xu The interhemispheric CA1 circuit governs rapid generalisation but not fear memory Nature Communications |
| author_facet |
Heng Zhou Gui-Jing Xiong Liang Jing Ning-Ning Song De-Lin Pu Xun Tang Xiao-Bing He Fu-Qiang Xu Jing-Fei Huang Ling-Jiang Li Gal Richter-Levin Rong-Rong Mao Qi-Xin Zhou Yu-Qiang Ding Lin Xu |
| author_sort |
Heng Zhou |
| title |
The interhemispheric CA1 circuit governs rapid generalisation but not fear memory |
| title_short |
The interhemispheric CA1 circuit governs rapid generalisation but not fear memory |
| title_full |
The interhemispheric CA1 circuit governs rapid generalisation but not fear memory |
| title_fullStr |
The interhemispheric CA1 circuit governs rapid generalisation but not fear memory |
| title_full_unstemmed |
The interhemispheric CA1 circuit governs rapid generalisation but not fear memory |
| title_sort |
interhemispheric ca1 circuit governs rapid generalisation but not fear memory |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-12-01 |
| description |
Previous work has documented a slow form of memory generalization although a rapid one is demanded. Here the authors elucidate the role of the interhemispheric CA1-CA1 projection in a form of rapid generalization of contextual fear memory via gradual potentiation of these synapses over 24 h. |
| url |
https://doi.org/10.1038/s41467-017-02315-4 |
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