Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases.

Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases.

DO (HLA-DO, in human; murine H2-O) is a highly conserved nonclassical major histocompatibility complex class II (MHC II) accessory molecule mainly expressed in the thymic medulla and B cells. Previous reports have suggested possible links between DO and autoimmunity, Hepatitis C (HCV) infection, and...

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Bibliographic Details
Main Authors:	Robin A Welsh, Nianbin Song, Catherine A Foss, Tatiana Boronina, Robert N Cole, Scheherazade Sadegh-Nasseri
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2020-02-01
Series:	PLoS Biology
Online Access:	https://doi.org/10.1371/journal.pbio.3000590

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