Increased Oxidative Phosphorylation is Required for Stemness Maintenance in Liver Cancer Stem Cells from Hepatocellular Carcinoma Cell Line HCCLM3 Cells

Increased Oxidative Phosphorylation is Required for Stemness Maintenance in Liver Cancer Stem Cells from Hepatocellular Carcinoma Cell Line HCCLM3 Cells

Cancer stem cells (CSCs) are considered to be the main cause of tumor recurrence, metastasis, and an unfavorable prognosis. Energy metabolism is closely associated with cell stemness. However, how the stemness of liver cancer stem cells (LCSCs) is regulated by metabolic/oxidative stress remains poor...

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Bibliographic Details
Main Authors: Ge Liu, Qing Luo, Hong Li, Qiuping Liu, Yang Ju, Guanbin Song
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
hepatocellular carcinoma
cancer stem cells
oxidative phosphorylation
glycolysis
cell metabolism
Online Access:https://www.mdpi.com/1422-0067/21/15/5276

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