Congenital Deficiency of Conventional Dendritic Cells Promotes the Development of Atopic Dermatitis-Like Inflammation

Congenital Deficiency of Conventional Dendritic Cells Promotes the Development of Atopic Dermatitis-Like Inflammation

Atopic dermatitis (AD) is a common pruritic inflammatory skin disease characterized by impaired epidermal barrier function and dysregulation of Thelper-2 (TH2)-biased immune responses. While the lineage of conventional dendritic cells (cDCs) are implicated to play decisive roles in T-cell immune res...

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Bibliographic Details
Main Authors: Yotaro Nishikawa, Tomohiro Fukaya, Takehito Fukui, Tomofumi Uto, Hideaki Takagi, Junta Nasu, Noriaki Miyanaga, Dieter Riethmacher, Narantsog Choijookhuu, Yoshitaka Hishikawa, Masahiro Amano, Katsuaki Sato
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
atopic dermatitis
dendritic cells
type 2 immune responses
immune homeostasis
homeostatic feedback loop
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.712676/full

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