Recent advances in antiviral interferon-stimulated gene biology [version 1; referees: 2 approved]
The interferon response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs), some of which encode effectors with varied antiviral functions. As screening technologies improve and mouse model development quickens, more ISGs a...
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2018-03-01
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| Online Access: | https://f1000research.com/articles/7-309/v1 |
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doaj-e5ac6f7fbb5246d9a15fce92ec1714c52020-11-25T01:23:31ZengF1000 Research LtdF1000Research2046-14022018-03-01710.12688/f1000research.12450.113482Recent advances in antiviral interferon-stimulated gene biology [version 1; referees: 2 approved]John W. Schoggins0Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USAThe interferon response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs), some of which encode effectors with varied antiviral functions. As screening technologies improve and mouse model development quickens, more ISGs are continually being identified, characterized mechanistically, and evaluated for protective roles in vivo. This review highlights selected recent findings of ISG effectors that contribute to our understanding of the interferon antiviral response.https://f1000research.com/articles/7-309/v1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
John W. Schoggins |
| spellingShingle |
John W. Schoggins Recent advances in antiviral interferon-stimulated gene biology [version 1; referees: 2 approved] F1000Research |
| author_facet |
John W. Schoggins |
| author_sort |
John W. Schoggins |
| title |
Recent advances in antiviral interferon-stimulated gene biology [version 1; referees: 2 approved] |
| title_short |
Recent advances in antiviral interferon-stimulated gene biology [version 1; referees: 2 approved] |
| title_full |
Recent advances in antiviral interferon-stimulated gene biology [version 1; referees: 2 approved] |
| title_fullStr |
Recent advances in antiviral interferon-stimulated gene biology [version 1; referees: 2 approved] |
| title_full_unstemmed |
Recent advances in antiviral interferon-stimulated gene biology [version 1; referees: 2 approved] |
| title_sort |
recent advances in antiviral interferon-stimulated gene biology [version 1; referees: 2 approved] |
| publisher |
F1000 Research Ltd |
| series |
F1000Research |
| issn |
2046-1402 |
| publishDate |
2018-03-01 |
| description |
The interferon response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs), some of which encode effectors with varied antiviral functions. As screening technologies improve and mouse model development quickens, more ISGs are continually being identified, characterized mechanistically, and evaluated for protective roles in vivo. This review highlights selected recent findings of ISG effectors that contribute to our understanding of the interferon antiviral response. |
| url |
https://f1000research.com/articles/7-309/v1 |
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