Caracterização do complexo de inclusão ropivacaína: beta-ciclodextrina

• Main Authors: Leonardo Fernandes Fraceto, Marcos Moisés Gonçalves, Carolina Morales Moraes, Daniele Ribeiro de Araújo, Luciana Zanella, Eneida de Paula, Thelma de Aguiar Pertinhez
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2007-10-01
• Series: Química Nova
• Subjects: ropivacaine; cyclodextrin; NMR
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500028

<abstract language="eng">Characteriza of the inclusion complex ropivacaine: beta-cyclodextrin. Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with beta-cyclodextrin (beta-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:beta-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:beta-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of beta-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.