p75NTR receptor – role in cell growth and apoptosis

 p75NTR receptor – role in cell growth and apoptosis

 The neurotrophins play an important role in the development of the nervous system. These trophic factors affect the cells through the neurotrophin receptors Trk and p75NTR. Trk (tyrosine kinase receptor) mediated signaling promotes survival and growth, while p75NTR-mediated signaling promotes cell...

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Bibliographic Details
Main Author: Anna Urbaniak
Format: Article
Language:English
Published: Index Copernicus International S.A. 2012-05-01
Series:Postępy Higieny i Medycyny Doświadczalnej
Subjects:
Apoptosis
Alzheimer’s Disease
p75NTR (neurotrophin receptor/low-affinity nerve growth factor receptor)
apoptoza
choroba alzheimera
p75NTR(receptor neurotrofin)
Online Access:http://journals.indexcopernicus.com/fulltxt.php?ICID=999026
Description
Summary: The neurotrophins play an important role in the development of the nervous system. These trophic factors affect the cells through the neurotrophin receptors Trk and p75NTR. Trk (tyrosine kinase receptor) mediated signaling promotes survival and growth, while p75NTR-mediated signaling promotes cell death. The structure of p75NTR and its role in the regulation of survival, growth and induction of apoptosis are discussed. p75NTR can interact with the aggregated form of Aβ peptides and by influencing protein tau hyperphosphorylation plays an important role in etiopathogenesis of Alzheimer’s disease.
ISSN:0032-5449
1732-2693

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