Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation

Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation

Terminal uridyltransferase 7 (TUT7) adds U-tails on diverse RNAs to promote degradation. Here the authors show that TUT7 is induced upon LPS treatment in macrophages and promotes decay of Regnase-1, thereby regulating the expression of a subset of cytokines, including IL-6.

Bibliographic Details
Main Authors: Chia-Ching Lin, Yi-Ru Shen, Chi-Chih Chang, Xiang-Yi Guo, Yun-Yun Young, Ting-Yu Lai, I-Shing Yu, Chih-Yuan Lee, Tsung-Hsien Chuang, Hsin-Yue Tsai, Li-Chung Hsu
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24177-7
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spelling doaj-e58f9225379f4a8285ee08d23b8361aa2021-07-04T11:46:01ZengNature Publishing GroupNature Communications2041-17232021-06-0112111610.1038/s41467-021-24177-7Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradationChia-Ching Lin0Yi-Ru Shen1Chi-Chih Chang2Xiang-Yi Guo3Yun-Yun Young4Ting-Yu Lai5I-Shing Yu6Chih-Yuan Lee7Tsung-Hsien Chuang8Hsin-Yue Tsai9Li-Chung Hsu10Institute of Molecular Medicine, National Taiwan UniversityInstitute of Molecular Medicine, National Taiwan UniversityInstitute of Molecular Medicine, National Taiwan UniversityInstitute of Molecular Medicine, National Taiwan UniversityInstitute of Molecular Medicine, National Taiwan UniversityInstitute of Molecular Medicine, National Taiwan UniversityLaboratory Animal Center, College of Medicine, National Taiwan UniversityInstitute of Molecular Medicine, National Taiwan UniversityImmunology Research Center, National Health Research InstitutesInstitute of Molecular Medicine, National Taiwan UniversityInstitute of Molecular Medicine, National Taiwan UniversityTerminal uridyltransferase 7 (TUT7) adds U-tails on diverse RNAs to promote degradation. Here the authors show that TUT7 is induced upon LPS treatment in macrophages and promotes decay of Regnase-1, thereby regulating the expression of a subset of cytokines, including IL-6.https://doi.org/10.1038/s41467-021-24177-7
collection DOAJ
language English
format Article
sources DOAJ
author Chia-Ching Lin
Yi-Ru Shen
Chi-Chih Chang
Xiang-Yi Guo
Yun-Yun Young
Ting-Yu Lai
I-Shing Yu
Chih-Yuan Lee
Tsung-Hsien Chuang
Hsin-Yue Tsai
Li-Chung Hsu
spellingShingle Chia-Ching Lin
Yi-Ru Shen
Chi-Chih Chang
Xiang-Yi Guo
Yun-Yun Young
Ting-Yu Lai
I-Shing Yu
Chih-Yuan Lee
Tsung-Hsien Chuang
Hsin-Yue Tsai
Li-Chung Hsu
Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
Nature Communications
author_facet Chia-Ching Lin
Yi-Ru Shen
Chi-Chih Chang
Xiang-Yi Guo
Yun-Yun Young
Ting-Yu Lai
I-Shing Yu
Chih-Yuan Lee
Tsung-Hsien Chuang
Hsin-Yue Tsai
Li-Chung Hsu
author_sort Chia-Ching Lin
title Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
title_short Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
title_full Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
title_fullStr Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
title_full_unstemmed Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
title_sort terminal uridyltransferase 7 regulates tlr4-triggered inflammation by controlling regnase-1 mrna uridylation and degradation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description Terminal uridyltransferase 7 (TUT7) adds U-tails on diverse RNAs to promote degradation. Here the authors show that TUT7 is induced upon LPS treatment in macrophages and promotes decay of Regnase-1, thereby regulating the expression of a subset of cytokines, including IL-6.
url https://doi.org/10.1038/s41467-021-24177-7
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