Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
Terminal uridyltransferase 7 (TUT7) adds U-tails on diverse RNAs to promote degradation. Here the authors show that TUT7 is induced upon LPS treatment in macrophages and promotes decay of Regnase-1, thereby regulating the expression of a subset of cytokines, including IL-6.
Bibliographic Details
| Main Authors: |
Chia-Ching Lin,
Yi-Ru Shen,
Chi-Chih Chang,
Xiang-Yi Guo,
Yun-Yun Young,
Ting-Yu Lai,
I-Shing Yu,
Chih-Yuan Lee,
Tsung-Hsien Chuang,
Hsin-Yue Tsai,
Li-Chung Hsu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-24177-7
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