(F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase

(F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase

Foot-and-mouth disease virus (FMDV) is an RNA virus belonging to the <i>Picornaviridae</i> family that contains three small viral proteins (VPgs), named VPg1, VPg2 and VPg3, linked to the 5&#8242;-end of the viral genome. These VPg proteins act as primers for RNA replication, which i...

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Bibliographic Details
Main Authors: Sonia de Castro, Cristina Ferrer-Orta, Alberto Mills, Gloria Fernández-Cureses, Federico Gago, Nuria Verdaguer, María-José Camarasa
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
foot-and-mouth disease virus
RNA-dependent RNA polymerase
5-fluorouracil
uridylylation inhibition
VPg
Online Access:https://www.mdpi.com/1420-3049/24/13/2360

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