Direct injection HILICâMS/MS analysis of darunavir in rat plasma applying supported liquid extraction

Direct injection HILICâMS/MS analysis of darunavir in rat plasma applying supported liquid extraction

A novel bioanalytical method was developed and validated for the quantitative determination of darunavir (DRV) in rat plasma by employing hydrophilic interaction chromatography and tandem mass spectrometry (HILICâMS/MS) with supported liquid extraction (SLE). Irbesartan (IRB) was used as an internal...

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Bibliographic Details
Main Authors: Bokka Ramesh, Nemali Manjula, Sistla Ramakrishna, Potturi Sita Devi
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Journal of Pharmaceutical Analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177914000422

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