Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation

ABSTRACT Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia. The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times. We...

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Main Authors:	Renata Salatti Ferrari, Leonardo Dalla Giacomassa Rocha Thomaz, Lucas Elias Lise Simoneti, Jane Maria Ulbrich, Cristiano Feijó Andrade
Format:	Article
Language:	English
Published:	Sociedade Brasileira de Pneumologia e Tisiologia 2019-03-01
Series:	Jornal Brasileiro de Pneumologia
Subjects:	Ischemia Reperfusion Fluorocarbons Lung transplantation Oxidative stress
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000400300&lng=en&tlng=en

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spelling	doaj-e58aa351e68d4b05a2314a049667ffd82020-11-25T01:14:54ZengSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia1806-37562019-03-0145410.1590/1806-3713/e20170288S1806-37132019000400300Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservationRenata Salatti FerrariLeonardo Dalla Giacomassa Rocha ThomazLucas Elias Lise SimonetiJane Maria UlbrichCristiano Feijó AndradeABSTRACT Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia. The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times. We performed histological analysis of and measured oxidative stress in the lungs of animals that received only preservation solution with low-potassium dextran (LPD) or vaporized PFC together with LPD. We conclude that vaporized PFC reduces the production of free radicals and the number of pulmonary structural changes resulting from cold ischemia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000400300&lng=en&tlng=enIschemiaReperfusionFluorocarbonsLung transplantationOxidative stress
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Renata Salatti Ferrari Leonardo Dalla Giacomassa Rocha Thomaz Lucas Elias Lise Simoneti Jane Maria Ulbrich Cristiano Feijó Andrade
spellingShingle	Renata Salatti Ferrari Leonardo Dalla Giacomassa Rocha Thomaz Lucas Elias Lise Simoneti Jane Maria Ulbrich Cristiano Feijó Andrade Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation Jornal Brasileiro de Pneumologia Ischemia Reperfusion Fluorocarbons Lung transplantation Oxidative stress
author_facet	Renata Salatti Ferrari Leonardo Dalla Giacomassa Rocha Thomaz Lucas Elias Lise Simoneti Jane Maria Ulbrich Cristiano Feijó Andrade
author_sort	Renata Salatti Ferrari
title	Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
title_short	Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
title_full	Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
title_fullStr	Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
title_full_unstemmed	Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
title_sort	effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
publisher	Sociedade Brasileira de Pneumologia e Tisiologia
series	Jornal Brasileiro de Pneumologia
issn	1806-3756
publishDate	2019-03-01
description	ABSTRACT Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia. The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times. We performed histological analysis of and measured oxidative stress in the lungs of animals that received only preservation solution with low-potassium dextran (LPD) or vaporized PFC together with LPD. We conclude that vaporized PFC reduces the production of free radicals and the number of pulmonary structural changes resulting from cold ischemia.
topic	Ischemia Reperfusion Fluorocarbons Lung transplantation Oxidative stress
url	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000400300&lng=en&tlng=en
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Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation

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