Streptococcus pyogenes M1T1 Variants Induce an Inflammatory Neutrophil Phenotype Including Activation of Inflammatory Caspases

Streptococcus pyogenes M1T1 Variants Induce an Inflammatory Neutrophil Phenotype Including Activation of Inflammatory Caspases

Invasive infections due to group A Streptococcus (GAS) advance rapidly causing tissue degradation and unregulated inflammation. Neutrophils are the primary immune cells that respond to GAS. The neutrophil response to GAS was characterised in response to two M1T1 isolates; 5448 and animal passaged va...

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Bibliographic Details
Main Authors: Jonathan G. Williams, Diane Ly, Nicholas J. Geraghty, Jason D. McArthur, Heema K. N. Vyas, Jody Gorman, James A. Tsatsaronis, Ronald Sluyter, Martina L. Sanderson-Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
inflammation
IL-1β
CD16
CD31
polymorphonuclear leukocyte
covS
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2020.596023/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2020.596023/full

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