Dysregulation of Antiviral Helicase Pathways in Systemic Lupus Erythematosus

Dysregulation of Antiviral Helicase Pathways in Systemic Lupus Erythematosus

In the autoimmune disease systemic lupus erythematosus (SLE), our normal antiviral defenses are inappropriately activated, resulting in over-activity of the type I interferon pathway. This increased activity of the type I IFN pathway is an important primary pathogenic factor in the disease. Emergin...

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Bibliographic Details
Main Authors: Luciana eOliveira, Nailú Angélica eSinicato, Mariana ePostal, Simone eAppenzeller, Timothy B. Niewold
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Genetics
Subjects:
Autoimmune Diseases
Genetic Predisposition to Disease
Interferons
systemic lupus erythematosus
helicases
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00418/full

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