<em>PDE4B</em> gene polymorphism in Russian patients with panic disorder

• Main Authors: Alena V Malakhova, Olga I Rudko, Vladimir V Sobolev, Artemii V Tretiakov, Elena A Naumova, Zarema G Kokaeva, Julia E Azimova, Eugene A Klimov
• Format: Article
• Language: English
• Published: AIMS Press 2019-08-01
• Series: AIMS Genetics
• Subjects: <em>pde4b</em> gene; rs10454453; rs502958; rs1040716; panic disorder; genetic association
• Online Access: https://www.aimspress.com/article/10.3934/genet.2019.3.55/fulltext.html
• ISSN: 2377-1143

<em>Background</em>: Panic disorder is a complex disease of unclear etiology but with an apparent genetic component. <em>PDE4B</em> gene product is involved in many cell processes owing to its function-regulation of the level of a second messenger cAMP. <em>PDE4B</em> gene polymorphism has been shown to be associated with some mental disorders including panic disorder. <em>Aims</em>: The goal of our study was to evaluate the role of 3 SNPs in the <em>PDE4B</em> gene in the development of panic disorder. <em>Methods</em>: 94 patients diagnosed with panic disorder according to the DSM-IV criteria were enrolled in the study. The population control group included 192 subjects. Genotyping was carried out by real-time PCR with TaqMan probes. <em>Results</em>: The investigated substitutions are not associated with panic disorder in general and in female/male cohorts (p &gt; 0.05). The analysis of complex genotypes demonstrated two protective complex genotypes (rs1040716:A, T + rs10454453:A + rs502958:A and rs1040716:A, T + rs502958:A) associated with panic disorder in general regardless of the patient’s gender (p &lt; 0.05). These genotypes did not correlate with the patient’s sex. <em>Conclusions:</em> We found two complex protective genotypes associated with panic disorder. This can be due to the fact that predisposition to the disease are associated with other genes, while <em>PDE4B</em> gene polymorphism reduces their effect.