Proteomic profiling reveals α1-antitrypsin, α1-microglobulin, and clusterin as preeclampsia-related serum proteins in pregnant women

Proteomic profiling reveals α1-antitrypsin, α1-microglobulin, and clusterin as preeclampsia-related serum proteins in pregnant women

Objective: Preeclampsia is a major cause of mortality in pregnant women but the underlying mechanism remains unclear to date. In this study, we attempted to identify candidate proteins that might be associated with preeclampsia in pregnant women by means of proteomics tools. Materials and methods: D...

Full description

Bibliographic Details
Main Authors:	Te-Yao Hsu, T'sang-T'ang Hsieh, Kuender D. Yang, Ching-Chang Tsai, Chia-Yu Ou, Bi-Hua Cheng, Yi-Hsun Wong, Hsuan-Ning Hung, An-Kuo Chou, Chang-Chun Hsiao, Hao Lin
Format:	Article
Language:	English
Published:	Elsevier 2015-10-01
Series:	Taiwanese Journal of Obstetrics & Gynecology
Subjects:	α1-antitrypsin α1-microglobulin clusterin preeclampsia proteomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S1028455915001540

Similar Items

THE DIAGNOSTIC AND CLINICAL VALUE OF DETERMINATION OF α1-ANTITRYPSIN PHENOTYPE IN SYSTEMIC VASCULITIDES
by: M. Yu. Pervakova, et al.
Published: (2017-04-01)

Suitability of α1-microglobulin reduction rate as a biomarker of removal efficiency of online hemodiafiltration: a retrospective cohort study
by: Kenji Sakurai, et al.
Published: (2021-02-01)

Prevalence of α-1-Antitrypsin gene mutations in Saudi Arabia
by: Badr Aljarallah, et al.
Published: (2011-01-01)

Mysteries of α1-antitrypsin deficiency: emerging therapeutic strategies for a challenging disease
by: Raafe Ghouse, et al.
Published: (2014-04-01)

Contents of plasmin, α1-antitrypsin and α2-macroglobulin in blood of patients with cerebral infarction and discircular encephalopathy before the treatment
by: N. A. Kuznetsova, et al.
Published: (2004-09-01)

Characterization of α1-antitrypsin as a heme oxygenase-1 suppressor in Alzheimer plasma
by: Olivier C. Maes, et al.
Published: (2006-10-01)

α1-Microglobulin Protects Against Bleeding-Induced Oxidative Damage in Knee Arthropathies
by: Staffan Larsson, et al.
Published: (2018-11-01)

A novel venom protein of the Asian bee (Apis cerana indica) with an affinity to human α1-microglobulin
by: Rosdiana Natzir, et al.
Published: (1999-01-01)

Proteomics in Deaths by Drowning: Diagnostic Efficacy of Apolipoprotein A1 and α-1Antitrypsin, Pilot Study
by: Diana Hernández-Romero, et al.
Published: (2020-09-01)

Prolastin, a pharmaceutical preparation of purified human α1-antitrypsin, blocks endotoxin-mediated cytokine release
by: Westin Ulla, et al.
Published: (2005-01-01)

Zapalenie tkanki podskórnej jako rzadki objaw kliniczny genetycznie uwarunkowanych zaburzeń α1-antytrypsyny – przegląd piśmiennictwa
by: Agata Maciejewska-Radomska, et al.
Published: (2011-08-01)

α1-Microglobulin Binds Illuminated Flavins and Has a Protective Effect Against Sublethal Riboflavin-Induced Damage in Retinal Epithelial Cells
by: Jesper Bergwik, et al.
Published: (2020-04-01)

Expression, Purification and Initial Characterization of Functional α1-Microglobulin (A1M) in Nicotiana benthamiana
by: Magnus L. R. Carlsson, et al.
Published: (2020-12-01)

Alpha-1 antitrypsin prevents the development of preeclampsia through suppression of oxidative stress
by: Yaling eFeng, et al.
Published: (2016-05-01)

Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers
by: Adriana Ordóñez, et al.
Published: (2021-05-01)

The heme and radical scavenger α1-microglobulin (A1M) confers early protection of the immature brain following preterm intraventricular hemorrhage
by: Olga Romantsik, et al.
Published: (2019-06-01)

The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process
by: Chiara Lenzi, et al.
Published: (2020-09-01)

Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies
by: Grigorios Kalapotharakos, et al.
Published: (2019-04-01)

Zapalenie tkanki podskórnej u nosicielki deficytowego wariantu S genu dla α1-antytrypsyny leczone skutecznie infliksymabem – opis przypadku
by: Michał Skroński, et al.
Published: (2011-08-01)

Chronic obstructive pulmonary disease (COPD): influence of clinic-anamnestic, anthropometric and functional characteristics on serum α-1-anitrypsin (AAT) in stable patients.
by: K. Yu. Gashynova
Published: (2018-10-01)

Development of a small molecule that corrects misfolding and increases secretion of Z α1‐antitrypsin
by: David A Lomas, et al.
Published: (2021-03-01)

A1M/α1-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation.
by: Martin eCederlund, et al.
Published: (2015-02-01)

Plasma α1-antitrypsin: A Neglected Predictor of Angiographic Severity in Patients with Stable Angina Pectoris
by: Hui Zhao, et al.
Published: (2015-01-01)

Binding of the human antioxidation protein α1-microglobulin (A1M) to heparin and heparan sulfate. Mapping of binding site, molecular and functional characterization, and co-localization in vivo and in vitro
by: Jesper Bergwik, et al.
Published: (2021-05-01)

Low Levels of IgG Recognizing the α-1-Antitrypsin Peptide and Its Association with Taiwanese Women with Primary Sjögren’s Syndrome
by: Yu-Sheng Chang, et al.
Published: (2017-12-01)

Enhanced secretion of human α1-antitrypsin expressed with a novel glycosylation module in tobacco BY-2 cell culture
by: Ningning Zhang, et al.
Published: (2019-01-01)

The Role of α<sub>1</sub>-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis—Therapeutic Opportunities in Hemolytic Conditions
by: Amanda Kristiansson, et al.
Published: (2020-09-01)

Therapeutic benefits of recombinant alpha1-antitrypsin IgG1 Fc-fusion protein in experimental emphysema
by: Katsuyuki Takeda, et al.
Published: (2021-07-01)

α<sub>1</sub>-Microglobulin (A1M) Protects Human Proximal Tubule Epithelial Cells from Heme-Induced Damage In Vitro
by: Amanda Kristiansson, et al.
Published: (2020-08-01)

Tumor necrosis factor alpha and alpha-1 antitrypsin gene variants in Serbian pediatric arterial ischemic stroke patients
by: Đorđević Valentina, et al.
Published: (2013-01-01)

Monocytes and Macrophages in Alpha-1 Antitrypsin Deficiency
by: Belchamber KBR, et al.
Published: (2020-12-01)

"Study of α1-Antitrypsin Phenotypes Frequencies in Patients with Primary Antibody Deficiency "
by: Mohammad R. Fazlollahi, et al.
Published: (2006-06-01)

PROINFLAMMATORY CYTOKINE PROFILE IN PATIENTS WITH DIFFERENT ALPHA-1-ANTITRYPSIN PHENOTYPES
by: M. Yu. Pervakova, et al.
Published: (2016-12-01)

Ferryl Hemoglobin and Heme Induce A<sub>1</sub>-Microglobulin in Hemorrhaged Atherosclerotic Lesions with Inhibitory Function against Hemoglobin and Lipid Oxidation
by: Dávid Pethő, et al.
Published: (2021-06-01)

Correlation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia
by: Mamatha Kunder, et al.
Published: (2017-03-01)

Characterization of heme binding to recombinant α1-microglobulin
by: Elena eKarnaukhova, et al.
Published: (2014-12-01)

<i>SERPINA1</i> Peptides in Urine as A Potential Marker of Preeclampsia Severity
by: Natalia Starodubtseva, et al.
Published: (2020-01-01)

Overexpression of alpha‐1 antitrypsin in mesenchymal stromal cells improves their intrinsic biological properties and therapeutic effects in nonobese diabetic mice
by: Lili Song, et al.
Published: (2021-02-01)

The Course of AαVal541 as a Proteinase 3 Specific Neo-Epitope after Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients
by: Iris G. M. Schouten, et al.
Published: (2021-07-01)

Urine alpha-1-microglobulin reliability in the diagnosis of pyelonephritis: a systematic review
by: Anoush Azarfar, et al.
Published: (2015-09-01)