Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous from non-cancerous OXPHOS and thus suffer from a limited th...

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Bibliographic Details
Main Authors: Margaret AM Nelson, Kelsey L McLaughlin, James T Hagen, Hannah S Coalson, Cameron Schmidt, Miki Kassai, Kimberly A Kew, Joseph M McClung, P Darrell Neufer, Patricia Brophy, Nasreen A Vohra, Darla Liles, Myles C Cabot, Kelsey H Fisher-Wellman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
mitochondria
cancer bioenergetics
OXPHOS
acute myeloid leukemia
mitochondrial proteomics
Online Access:https://elifesciences.org/articles/63104

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