α/β-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli

α/β-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli

Objective: α/β-Hydrolase domain-6 (ABHD6) is a newly identified monoacylglycerol (MAG) lipase. We recently reported that it negatively regulates glucose stimulated insulin secretion (GSIS) in the β cells by hydrolyzing lipolysis-derived MAG that acts as a metabolic coupling factor and signaling mole...

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Bibliographic Details
Main Authors: Shangang Zhao, Pegah Poursharifi, Yves Mugabo, Emily J. Levens, Kevin Vivot, Camille Attane, Jose Iglesias, Marie-line Peyot, Erik Joly, S.R. Murthy Madiraju, Marc Prentki
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Molecular Metabolism
Subjects:
α/β-Hydrolase domain-6
Monoacylglycerol
Insulin secretion
Pancreatic islets
Cytosolic Ca2+
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001829

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