Indomethacin Increases Neurogenesis across Age Groups and Improves Delayed Probe Trial Difference Scores in Middle-Aged Rats

Indomethacin Increases Neurogenesis across Age Groups and Improves Delayed Probe Trial Difference Scores in Middle-Aged Rats

We tested whether indomethacin or rosiglitazone treatment could rejuvenate spatial ability and hippocampal neurogenesis in aging rats. Young (4 mo; n = 30), middle-aged (12 mo; n = 31), and aged (18 mo; n = 31) male Fischer 344 rats were trained and then tested in a rapid acquisition water maze task...

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Bibliographic Details
Main Authors: James A. McGuiness, Rachel B. Scheinert, Aditya Asokan, Vivien-Charlott Stadler, Christian S. Lee, Asha Rani, Ashok Kumar, Thomas C. Foster, Brandi K. Ormerod
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
hippocampal neurogenesis
subependymal neurogenesis
learning
memory
microglia
aging
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00280/full

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