Activation of the Nrf2-ARE Pathway Attenuates Hyperglycemia-Mediated Injuries in Mouse Podocytes

Activation of the Nrf2-ARE Pathway Attenuates Hyperglycemia-Mediated Injuries in Mouse Podocytes

Background: Damage to podocytes caused by excessive reactive oxygen species (ROS) contributes to onset and progression of diabetic kidney disease (DKD). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a redox-sensing transcription factor that can induce the expression of antioxidant enzymes. W...

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Bibliographic Details
Main Authors:	Cheng Wang, CuiCui Li, Hui Peng, Zengchun Ye, Jun Zhang, Xun Liu, Tanqi Lou
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2014-08-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Tert-Butylhydroquinone Nuclear factor (erythroid-derived 2)-like 2 Antioxidant response element High glucose Podocyte
Online Access:	http://www.karger.com/Article/FullText/366307

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