Cisplatin-Resistant Gastric Cancer Cells Promote the Chemoresistance of Cisplatin-Sensitive Cells via the Exosomal RPS3-Mediated PI3K-Akt-Cofilin-1 Signaling Axis

Cisplatin-Resistant Gastric Cancer Cells Promote the Chemoresistance of Cisplatin-Sensitive Cells via the Exosomal RPS3-Mediated PI3K-Akt-Cofilin-1 Signaling Axis

Cisplatin is an important agent in first-line chemotherapy against gastric cancer (GC). However, consequential drug resistance limits its effectiveness for the treatment of GC. In this study, a cisplatin resistant gastric cancer cell line SGC7901R was determined by LC-MS/MS with increased exosomal l...

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Bibliographic Details
Main Authors: Meng-Yao Sun, Bo Xu, Qiu-Xue Wu, Wen-Lian Chen, Si Cai, Hui Zhang, Qing-Feng Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
gastric cancer
cisplatin resistance
exosome
RPS3
PI3K-Akt-cofilin-1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.618899/full

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