Lens differentiation is controlled by the balance between PDGF and FGF signaling.

Lens differentiation is controlled by the balance between PDGF and FGF signaling.

How multiple receptor tyrosine kinases coordinate cell fate determination is yet to be elucidated. We show here that the receptor for platelet-derived growth factor (PDGF) signaling recruits the p85 subunit of Phosphoinositide 3-kinase (PI3K) to regulate mammalian lens development. Activation of PI3...

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Bibliographic Details
Main Authors:	Hongge Li, Yingyu Mao, Michael Bouaziz, Honglian Yu, Xiuxia Qu, Fen Wang, Gen-Sheng Feng, Carrie Shawber, Xin Zhang
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2019-02-01
Series:	PLoS Biology
Online Access:	https://doi.org/10.1371/journal.pbio.3000133

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