Impact of Obeticholic acid Exposure on Decompensation and Mortality in Primary Biliary Cholangitis and Cirrhosis

Impact of Obeticholic acid Exposure on Decompensation and Mortality in Primary Biliary Cholangitis and Cirrhosis

Obeticholic acid (OCA) is approved for the treatment of patients with primary biliary cholangitis (PBC) who are partial responders or intolerant to ursodeoxycholic acid. Reports of serious liver injury have raised concerns about its safety in cirrhosis. We investigated the effects of treatment with...

Full description

Bibliographic Details
Main Authors:	Binu V. John, Kaley Schwartz, Cynthia Levy, Bassam Dahman, Yangyang Deng, Paul Martin, Tamar H. Taddei, David E. Kaplan
Format:	Article
Language:	English
Published:	Wiley 2021-08-01
Series:	Hepatology Communications
Online Access:	https://doi.org/10.1002/hep4.1720

Similar Items

Real‐World Effectiveness of Obeticholic Acid in Patients with Primary Biliary Cholangitis
by: Surain B. Roberts, et al.
Published: (2020-09-01)

Real-world experience with obeticholic acid in patients with primary biliary cholangitis
by: Daphne D’Amato, et al.
Published: (2021-04-01)

New developments in the treatment of primary biliary cholangitis – role of obeticholic acid
by: Jhaveri MA, et al.
Published: (2017-08-01)

Obeticholic acid for the treatment of primary biliary cholangitis in adult patients: clinical utility and patient selection
by: Bowlus CL
Published: (2016-09-01)

Obeticholic acid is associated with improvements in AST-to-platelet ratio index and GLOBE score in patients with primary biliary cholangitis
by: Maren H. Harms, et al.
Published: (2021-02-01)

Response Rate and Impact on Lipid Profiles of Obeticholic Acid Treatment for Patients with Primary Biliary Cholangitis: A Meta-Analysis
by: Yuan Gao, et al.
Published: (2021-01-01)

Time to Make the Change from ‘Primary Biliary Cirrhosis’ to ‘Primary Biliary Cholangitis’
by: Angela C Cheung, et al.
Published: (2015-01-01)

Primary sclerosing cholangitis and Biliary cirrhosis associated with Ulcerative colitis
by: Aleem Ahmed Khan, et al.
Published: (2011-07-01)

Consensus on the diagnosis and management of primary biliary cirrhosis (cholangitis)(2015)
by: Chinese Society of Hepatology, Chinese Medical Association;, et al.
Published: (2015-12-01)

Fibrates for Primary Biliary Cholangitis: What’s All the Hype?
by: Cynthia Levy
Published: (2017-09-01)

Primary biliary cirrhosis and autoimmune cholangitis are not associated with coeliac disease in Crete
by: Dimoulios Philippos, et al.
Published: (2002-03-01)

Obeticholic Acid Decreases Intestinal Content of Enterococcus in Rats With Cirrhosis and Ascites
by: Kathleen Yan, et al.
Published: (2021-09-01)

Rituximab for the treatment of fatigue in primary biliary cholangitis (formerly primary biliary cirrhosis): a randomised controlled trial
by: Amardeep Khanna, et al.
Published: (2018-04-01)

Impact of Microbes on the Pathogenesis of Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangitis (PSC)
by: Jochen Mattner
Published: (2016-11-01)

Primary biliary cholangitis
by: I. M. Iljinsky, et al.
Published: (2021-04-01)

ERCP improves mortality in acute biliary pancreatitis without cholangitis
by: Aleksey A. Novikov, et al.
Published: (2021-05-01)

The relation between plasma tyrosine concentration and fatigue in primary biliary cirrhosis and primary sclerosing cholangitis
by: Vrolijk Jan, et al.
Published: (2005-03-01)

Risk of endoscopic biliary interventions in primary sclerosing cholangitis is similar between patients with and without cirrhosis.
by: Moritz Peiseler, et al.
Published: (2018-01-01)

Baricitinib and primary biliary cholangitis
by: Stuart C. Gordon, et al.
Published: (2021-01-01)

Novel Insights of Primary Sclerosing Cholangitis and Primary Biliary Cholangitis
by: Dong-Won Ahn
Published: (2020-05-01)

Validity of an Automated Algorithm to Identify Cirrhosis Using Electronic Health Records in Patients with Primary Biliary Cholangitis
by: Lu M, et al.
Published: (2020-11-01)

Soluble CD163 Is a Predictor of Mortality in Patients With Decompensated Cirrhosis
by: Yue Zhang, et al.
Published: (2021-07-01)

Serum Cystatin C Predicts Mortality in HBV-Related Decompensated Cirrhosis
by: JianPing Wu, et al.
Published: (2019-01-01)

The performance of prognostic models as predictors of mortality in patients with acute decompensation of cirrhosis
by: Leonardo Fayad, et al.
Published: (2015-01-01)

COVID-19 in decompensated cirrhosis
by: O. V. Tashchyan, et al.
Published: (2021-01-01)

Improving Survival in Decompensated Cirrhosis
by: Amar Nath Mukerji, et al.
Published: (2012-01-01)

Management options in decompensated cirrhosis
by: Shah NL, et al.
Published: (2015-07-01)

Evaluation of the United Kingdom‐primary biliary cholangitis and global primary biliary cholangitis group prognostic models for primary biliary cholangitis patients treated with ursodeoxycholic acid in the U.S. population
by: Mohammad Alomari, et al.
Published: (2020-04-01)

Obeticholic acid reduces biliary and hepatic matrix metalloproteinases activity in rat hepatic ischemia/reperfusion injury.
by: Andrea Ferrigno, et al.
Published: (2020-01-01)

Obeticholic acid reduces biliary and hepatic matrix metalloproteinases activity in rat hepatic ischemia/reperfusion injury
by: Andrea Ferrigno, et al.
Published: (2020-01-01)

A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced Ductopenias
by: Chih-Te Wu, et al.
Published: (2004-01-01)

Primary biliary cholangitis: Diagnosis and treatment
by: Michael Chew, et al.
Published: (2018-06-01)

Current understanding of primary biliary cholangitis
by: Atsushi Tanaka
Published: (2021-01-01)

Primary biliary cholangitis: opportunities and challenges
by: WANG Qixia, et al.
Published: (2017-11-01)

Research advances in primary biliary cholangitis
by: DUAN Weijia, et al.
Published: (2016-11-01)

Advances in pharmacotherapy for primary biliary cholangitis
by: LEI Liujie, et al.
Published: (2017-06-01)

Sarcoidosis and Primary Biliary Cholangitis- An Overlap
by: Akshatha Manohar, et al.
Published: (2021-07-01)

Fluvoxamine for fatigue in primary biliary cirrhosis and primary sclerosing cholangitis: a randomised controlled trial [ISRCTN88246634]
by: Hansen Bettina E, et al.
Published: (2004-07-01)

Primary biliary cirrhosis-primary sclerosing cholangitis overlap syndrome with lupus erythematosus profundus: a case report
by: WEI Huafang, et al.
Published: (2016-06-01)

Human leukocyte antigen associations in Finnish liver transplantations due to primary sclerosing cholangitis and primary biliary cirrhosis
by: Matinlauri Irma, et al.
Published: (2007-03-01)