Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids.

Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids.

BACKGROUND: Stromal fibroblasts are important determinants of tumor cell behavior. They act to condition the tumor microenvironment, influence tumor growth, support tumor angiogenesis and affect tumor metastasis. Heparan sulfate proteoglycans, present both on tumor and stromal cells, interact with a...

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Bibliographic Details
Main Authors: Cecilia Österholm, Ning Lu, Åsa Lidén, Tine V Karlsen, Donald Gullberg, Rolf K Reed, Marion Kusche-Gullberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3405129?pdf=render

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http://europepmc.org/articles/PMC3405129?pdf=render

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