Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F.
A somatic activating mutation (V617F) in the JAK2 tyrosine kinase was recently discovered in the majority of patients with polycythemia vera (PV), and some with essential thrombocythemia (ET) and chronic idiopathic myelofibrosis. However, the role of mutant JAK2 in disease pathogenesis is unclear.We...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-12-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC1762384?pdf=render |