Upregulated MELK Leads to Doxorubicin Chemoresistance and M2 Macrophage Polarization via the miR-34a/JAK2/STAT3 Pathway in Uterine Leiomyosarcoma

Upregulated MELK Leads to Doxorubicin Chemoresistance and M2 Macrophage Polarization via the miR-34a/JAK2/STAT3 Pathway in Uterine Leiomyosarcoma

Uterine leiomyosarcoma (ULMS) is the most lethal gynecologic malignancy with few therapeutic options. Chemoresistance prevails as a major hurdle in treating this malignancy, yet the mechanism of chemoresistance remains largely unclear. In this study, we certified MELK as a poor prognostic marker thr...

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Bibliographic Details
Main Authors: Zhiwei Zhang, Chenggong Sun, Chengcheng Li, Xinlin Jiao, Brannan B. Griffin, Samina Dongol, Huan Wu, Chenyi Zhang, Wenyu Cao, Ruifen Dong, Xingsheng Yang, Qing Zhang, Beihua Kong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
MELK
uterine leiomyosarcoma
chemoresistance
apoptosis
M2 macrophage
JAK2
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00453/full

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