SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus.

SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus.

Sterol regulatory element binding proteins (SREBPs) are a class of basic helix-loop-helix transcription factors that regulate diverse cellular responses in eukaryotes. Adding to the recognized importance of SREBPs in human health, SREBPs in the human fungal pathogens Cryptococcus neoformans and Aspe...

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Bibliographic Details
Main Authors: Michael Blatzer, Bridget M Barker, Sven D Willger, Nicola Beckmann, Sara J Blosser, Elizabeth J Cornish, Aurelien Mazurie, Nora Grahl, Hubertus Haas, Robert A Cramer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3228822?pdf=render

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