Effects of Berberise Vulgaris fruit extract on bloodcholesterol and triglyceride in hyperlipidemic patients

• Main Authors: A. Farhadi, K. Gavadifar, A . Farhadi
• Format: Article
• Language: fas
• Published: Semnan Univeristy of Medical Sciences 2008-05-01
• Series: Majallah-i ̒Ilmī-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Simnān
• Subjects: Hyper-lipidemia; Triglyceride; Cholesterol; Berberise Vulgaris.
• Online Access: http://www.koomeshjournal.ir/browse.php?a_code=A-10-4-221&slc_lang=en&sid=1&ftxt=1

Introduction: Previous studies have indicated that aqueous extract of Berberise Vulgaris (BV) hasability to decrease plasma levels of lipids probably via stimulating lipolysis pathways in liver. The aimof this study was to determine the effects of BV Fruit extracts on plasma levels of cholesterol andtriglyceride.Materials and Methods: In this semi-experimental study, 89 patients who suffering fromhypercholesterolemia and hyper-triglyceridemia were taken and divided into case and control groupusing a random pattern. The case group was received aqueous extract of fruit of BV and the controlgroup received a placebo at the same volume. Fasting blood sample was drawn for measurement ofcholesterol and triglycerides. Data were analyzed with student t- test.Results: Results showed that extract of BV fruits significantly decreased the amount of total bloodcholesterol and triglyceride in case group as compared with control group (P<0.001).Conclusion: Finding above indicated that extract of BV could play an important role in lowering ofcholesterol and triglyceride in hyper-lipidemic patients. However, more studies are needed todetermine the underlying mechanisms.