The Study on toxicity and biological activities of Aconiti ciliare tuber Pharmacopuncture in Rats Original Articles

• Main Authors: Kim Sungchul, Ahn Seong-Hun, Kim Sungha, Lee Sangkwan, Song Bong-Keun
• Format: Article
• Language: English
• Published: Korean Pharmacopuncture Institute 2011-03-01
• Series: Journal of Pharmacopuncture
• Subjects: Aconiti ciliare tuber; Pharmacopuncture; toxicity test; antioxidant activity; biological activity
• Online Access: http://dx.doi.org/10.3831/KPI.2011.14.1.025

Objective: We investigate toxicity of Aconiti ciliare tuber and antioxidant activity of Aconiti ciliare tuber Pharmacopuncture to develop safe Aconiti ciliare tuber Pharmacopuncture and find out the effect. Methods: In order to investigate toxicity of Aconiti ciliare tuberm, we administered Aconiti ciliare tuberm orally to rats and examined the survival rate, comparing with the survival rate of rats administered by Radix aconitum simmered with Semen Glycine and Radix Glycyrrhizae. We examined the in vitro biological activity of Aconiti ciliare tuber Pharmacopuncture, including the total polyphenol content, and ABTS radical scavenging. Results and Conclusions: The LD50 of Radix aconitum simmered with Semen Glycine and Radix Glycyrrhizae was 9.0g/kg, on the other hand, the LD50 of Aconiti ciliare tuberm was more than 15g/kg.The total polyphenol contents of Aconiti ciliare tuberm Pharmacopuncture was 2.31mg/L. The 2,2'-azinobis-3-ehtlbezothiazoline-6-sulfonic acid radical decolorization (ABTS) was 10.26%.We conclude that Aconiti ciliare tuberm is not highly toxic, Aconiti ciliare tuber Pharmacopuncture has a little antioxidant effect.