Impact of 4D CT for treatment planning of moving targets: a computer-based biological evaluation

• Main Authors: Helf Eike, Waletzko Oliver, Mehrens Christian, Rohn Ralf, Block Andreas
• Format: Article
• Language: English
• Published: De Gruyter 2017-09-01
• Series: Current Directions in Biomedical Engineering
• Subjects: 4d ct; tumor control probability; normal tissue complication probability; vmat; 3d-crt; treatment planning
• Online Access: https://doi.org/10.1515/cdbme-2017-0140
• ISSN: 2364-5504

This study deals with comparison of conventional and 4D CT (GE Lightspeed) planning on the tumour control probability (TCP), using the TCP model of the AAPM-Report Task Group 166. In the first step a VMAT treatment plan was calculated (Varian Eclipse 13.7) on basis of conventional CT data. This treatment plan was transferred to the complete 4D CT, which represents the tumour volume in motion. Due to the increased volume and the resulting decrease of tumour coverage the TCP went down from 97,6% to 91,2%. After adding an internal target volume (ITV, ICRU 62) to the conventional CT according to our clinical protocols (1,0 cm cc and 0,3 cm axial plane) the TCP increased to 98,0% when applying the conventional plan to the 4D CT. This finding demonstrates the need of 4D CT for moving tumours in chest and abdomen region.