Protein Synthesis Inhibition and Activation of the c-Jun N-Terminal Kinase Are Potential Contributors to Cisplatin Ototoxicity

Protein Synthesis Inhibition and Activation of the c-Jun N-Terminal Kinase Are Potential Contributors to Cisplatin Ototoxicity

Cisplatin has been regarded as an effective and versatile chemotherapeutic agent for nearly 40 years. Though the associated dose-dependent ototoxicity is known, the cellular mechanisms by which cochleovestibular hair cell death occur are not well understood. We have previously shown that aminoglycos...

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Bibliographic Details
Main Authors: Brian D. Nicholas, Shimon Francis, Elizabeth L. Wagner, Sibo Zhang, Jung-Bum Shin
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cisplatin
ototoxicity
inner ear
hair cell
protein synthesis
BONCAT
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00303/full

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